The authors have used Horse Gene Expression Microarray data from matched equine sarcoids and tumour-distant skin samples.
In total, 901 significantly differentially expressed genes (DEGs) between lesional and healthy skin samples have been identified (fold change ≥ 2; P < 0.05).
The large subset of DEGs, with decreased expression, was associated with a suppression of malignant transformation, whereas several overexpressed genes were involved in the processes associated with growth and progression of a tumour or immune system activity.
Our results, as a first to date, showed comprehensive transcriptome analysis of skin tumour in horses and pinpointed significant pathways and genes related with oncogenesis processes.
Source: Semik, E., Gurgul, A., Ząbek, T., Ropka-Molik, K., Koch, C., Mählmann, K. and Bugno-Poniewierska, M. (2016), Transcriptome analysis of equine sarcoids. Veterinary and Comparative Oncology. doi: 10.1111/vco.12279
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