Cytogenetic analysis showed two cell lines, one with X monosomy—37,X [90% of the analysed metaphase spreads], and other line had 38 chromosomes with normal X chromosome and abnormally small Y-derived chromosome—38,X,der(Y) [10%].
Further fluorescence in situ hybridization study with telomeric probe revealed a ring structure of the der(Y).
Eight Y chromosome-specific genes, SRY, TETY1, TETY2, CUL4BY, CYORF15, HSFY, FLJ36031Y and ZFY, were detected.
We conclude that the described abnormality of the reproductive system, leading to sterility, was caused by a very rare type of chromosomal mosaicism—37,X/38,X,r(Y).
Source: Szczerbal I, Stachowiak M, Nowacka-Woszuk J, Dzimira S, Szczepanska K, Switonski M. Disorder of sex development in a cat with chromosome mosaicism 37,X/38,X,r(Y). Reprod Dom Anim. 2017;52:914–917. https://doi.org/10.1111/rda.12968
|
