A 5-year-old, 29-kg, female Labrador retriever developed tachypnea, tachycardia, and ataxia following ingestion of approximately 48 mg/kg of phenylpropanolamine.
Initial diagnostic tests showed multiform ventricular tachycardia, left ventricular dilatation with a focal dyskinetic region in the dorsal interventricular septum, and elevations in creatinine kinase and cardiac troponin I.
All abnormalities resolved within 6 months.
The transient electrocardiographic, echocardiographic, and biochemical abnormalities were consistent with myocardial necrosis from infarction or direct catecholamine-induced myocardial toxicity.
Source: John M. Crandell, Wendy A. Ware (2005): Cardiac Toxicity From Phenylpropanolamine Overdose in a Dog. In: Journal of the American Animal Hospital Association 41:413-420 (2005)
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