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Gemcitabine as radiosensitizer for nonresectable oral SCC in cats
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Squamous cell carcinomas (SCC) in the oral cavity of cats are fairly common seen. When diagnosed, they are often in a nonresectable stage, and they tend to response very poor to chemotherapy. This small study on eight cats describes a very interesting and rather effective therapeutic alternative: a radiosensitizer plus radiotherapy!
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Eight cats with locally advanced, oral squamous cell carcinoma (SCC) were treated with a combination of gemcitabine and palliative radiotherapy.
Low-dose gemcitabine was administered twice weekly (25 mg/m2) in conjunction with megavoltage radiation in 6 Gray (Gy) fractions for a total dose of 36 Gy.
Responses included two complete and four partial responses, and two cats had no response to therapy.
Median duration of remission was 42.5 days (range, 11 to 85 days).
Median survival time was 111.5 days (range, 11 to 234 days).
This data suggests that a combination of low-dose gemcitabine and palliative radiation therapy may be tolerable for cats with oral SCC and may cause a therapeutic benefit.
Source: Pamela D. Jones, Louis-Philippe de Lorimier, Barbara E. Kitchell, John M. Losonsky (2003): Gemcitabine as a Radiosensitizer for Nonresectable Feline Oral Squamous Cell Carcinoma. In: Journal of the American Animal Hospital Association 39:463-467 (2003)
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