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Update in diagnosis, prognosis and therapy of portosystemic shunts
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In this study, 64 dogs diagnosed with portosystemic shunts between the years 1993 and 2001 were reviewed. Sensitivities of screening tests and abdominal ultrasonographic evaluation for the detection of portosystemic shunting were evaluated. Prognosis for surgically treated shunts was also evaluated.
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The results indicated that both paired serum bile acids and blood ammonia levels were useful screening tests for portosystemic shunting.
However, paired bile acid tests were significantly more sensitive than blood ammonia levels.
Overall postoperative mortality rates for extrahepatic shunts and intrahepatic shunts were 8.7% and 20%, respectively. Postoperative mortality rates were slightly higher for animals treated with partial ligation when compared to those treated with ameroid ring placement, although this did not reach statistical significance.
Long-term complication rates for animals with single extrahepatic portosystemic shunts treated with complete ligation, ameroid ring placement, and partial ligation alone were 9%, 15.4%, and 42%, respectively. Animals >2 years of age with extrahepatic shunts had almost identical postoperative mortality and long-term complication rates as animals < or = 2 years of age.
No animal in this study had paired bile acid samples within the reference range postoperatively, indicating continued abnormal liver function after surgery.
Source: Winkler JT, Bohling MW, Tillson DM, Wright JC, Ballagas AJ. (2003): Portosystemic shunts: diagnosis, prognosis, and treatment of 64 cases (1993-2001). In: J Am Anim Hosp Assoc 2003 Mar-Apr;39(2):169-85
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Acyclovir and Cyprinid herpesvirus 3 multiplication in vitro
Cyprinid herpesvirus 3 (CyHV‐3), also known as koi herpesvirus (KHV), is an aetiological agent of a virulent and lethal disease in common and koi carp. In this study, the authors examined in vitro the anti‐CyHV‐3 activity of acyclovir (ACV), nucleoside analogue commonly used against human herpesviruses, as well as acyclovir monophospate (ACV‐MP).
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