| |
Epithelioid variant of hemangioma and hemangiosarcoma in various species
 |
Epithelioid hemangiomas, hemangioendotheliomas, and angiosarcomas are well recognized histologic variants of endothelial tumors in humans that in the past have been confused with neoplasms of epithelial or histiocytic origin. This brandnew article describes a novel group of vascular tumors in domestic animals of which there are only 3 previous cases reported in the veterinary literature!
|
|
|
| |
We describe 12 epithelioid endothelial vascular tumors in 8 dogs, 3 horses, and 1 cow that share microscopic features with these tumors in humans.
Ten tumors were located within the dermis and subcutis, 1 in the gastrocnemius tendon, and 1 in the skeletal muscle of the thigh.
Key histologic features were the plump, epithelioid appearance of neoplastic endothelial cells and occasional cytoplasmic vacuolation, which rarely contained a single erythrocyte.
Patterns of epithelioid endothelial cell growth ranged from conventional vasoformative structures to glandlike acini and short ducts to solid, sheetlike arrangements.
All tumors were positive for endothelial markers: 12/12 (100%) were positive for von Willebrand factor with variable intensity and distribution and 9/9 (100%) were positive for CD31. All 12 were negative for cytokeratin.
We subdivided these tumors into epithelioid hemangiomas (n = 3) and hemangiosarcomas (n = 9) based on conventional morphologic criteria, growth pattern (invasive or not), and metastasis (known in 1 case at the time of biopsy).
Additional follow-up information obtained by a written questionnaire was available for 6/12 (50%) animals and revealed local recurrence in 3 animals (1 epithelioid hemangioma and 2 epithelioid hemangiosarcoma) and regional metastasis in 3 animals (all epithelioid hemangiosarcomas).
This series represents a novel group of vascular tumors in domestic animals of which there are only 3 previous cases reported in the veterinary literature.
Source: A. L. Warren and B. A. Summers (2007): Epithelioid Variant of Hemangioma and Hemangiosarcoma in the Dog, Horse, and Cow. In: Vet Pathol 44:15-24 (2007)
Tell a friend
|
Print version
|
Send this article
|
| |
Limbal squamous cell carcinoma in a Rocky Mountain Horse and genetics Subconjunctival bupivacaine, lidocaine, and mepivacaine and the corneal sensitivity in horsesClodronate in horses with lamenessValacyclovir in horses with equine multinodular pulmonary fibrosisRadiculopathy associated with forelimb lameness in horsesBiological variations of routine blood parameters in horsesPrognosis for horses with deep digital flexor tendon injury after penetrating woundPossible maternal effect for the pace trait of horsesFlecainide on induced atrial fibrillation in horsesSonographic technique to identify manica flexoria tears in horsesNovel prototype dynamic laryngoplasty system on arytenoid abductionLipid peroxidation biomarkers in equine neuroaxonal dystrophy
|
