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Insulin-resistant diabetes mellitus in feline acromegaly
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A cat with insulin-resistant diabetes mellitus - of course a steroid-induced diabetes is the most likely differential diagnosis. But also other endocrine problems need to be considered, and feline acromegaly - although rare - can be very difficult to diagnose...
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Acromegaly is characterized by chronic excessive growth hormone (GH) secretion by the pituitary gland.
Feline acromegaly is most commonly caused by a functional pituitary tumor.
Definitive diagnosis can be difficult because of the gradual disease onset, subtle clinical signs, unavailability of relevant laboratory tests, and client financial investment.
The most significant clinical finding of acromegaly is the presence of insulin-resistant diabetes mellitus.
Diagnosis is currently based upon brain imaging and measurement of serum GH and/or insulin-like growth factor-1 concentrations.
Definitive treatment in cats is not well described, but radiation therapy appears promising.
Source: Hurty CA, Flatland B. (2005): Feline acromegaly: a review of the syndrome. In: J Am Anim Hosp Assoc. 2005 Sep-Oct;41(5):292-7.
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