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Abnormal ocular pigmentation with glaucoma in dogs
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Glaucomas are diagnosed in small animal practice on a regular base. Over the last couple years, a combined occurence of ocular pigment deposition and glaucoma has been described in Cairn Terriers and also in 2 other breeds: Boxer (two cases) and the Labrador Retriever (one case).
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Six dogs were referred to the Ophthalmology section of the Department of Clinical Sciences of Companion Animals and to a private referral clinic because of glaucoma or blindness in one or both eyes. In five cases ophthalmic examination showed pigment depositions in the sclera around the entire circumference of the perilimbal zone. Eight enucleated eyes (four eyes of two Cairn Terriers, three eyes of two Boxers and one eye of a Labrador Retriever) were examined microscopically.
All eyes showed the same findings: an extensive infiltration of large melanin-containing cells with an eccentric nucleus, located in the iris, ciliary body, retina, choroids and sclera. Transmission electron microscopy of two of the examined eyes revealed that the morphology of most of these cells was consistent with melanophages.
While reports in the veterinary literature concerning this condition are limited the cells concerned have been described to be melanocytes. Further research is needed to conclusively identify the cell type. As described in the present report, the histologic and transmission electron microscopic findings suggest a different etiology of the ocular pigment deposition and glaucoma compared with the pigment dispersal syndrome.
Source: Roswitha R.O.M. van de Sandt, Michael H. Boevé, Frans C. Stades, Maria J.L. Kik (2003): Abnormal ocular pigment deposition and glaucoma in the dog. In: Veterinary Ophthalmology
Volume 6 Issue 4 December 2003 p 273
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