Two studies were conducted under laboratory conditions with 16 dogs to investigate the analgesic effectiveness of a low dose of ketoprofen in a short-term sodium urate crystal-induced synovitis model of arthritis.
The effect of the treatment, defined as the improvement in peak vertical force weight bearing, was evaluated in the first study at three dose levels. A single oral dose of 0路25 mg/kg ketoprofen was significantly better (P<0路01) than the control (0 mg), but doses of 0路5 and 0路75 mg/kg did not improve the dogs` weight bearing further.
The second study investigated the efficacy and safety of the 0路25 mg/kg dose administered daily for 30 days. The beneficial effects of ketoprofen at this dose were constant, with the treated dogs bearing 89路1 per cent of the baseline vertical force four hours after the induction of arthritis on day 1 and 92路2 per cent on day 29, compared with 42 per cent and 34 per cent of the baseline in the untreated dogs.
No gastrointestinal or other side effects were observed during the treatment.
Source: H A W. Hazewinkel,W E van den Brom, L F H. Theijse, M Pollmeie, P. D. Hanson (2003): Reduced dosage of ketoprofen for the short-term and long-term treatment of joint pain in dogs. In: The Vet Record,152, 1, 11-14, 4th January 2003
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