Immunohistochemically, the neoplastic cells were positive for vimentin, S-100 protein, neurone-specific enolase and synaptophysin, but negative for cytokeratin, neurofilament protein, glial fibrillary acidic protein and chromogranin A.
On ultrastructural observation, aggregates of thin cytoplasmic processes were frequently seen among the neoplastic cells.
Based on these features, the tumour was diagnosed as a neuroblastoma.
Source: Masaki Michishita, Yuki Momozawa, Takuya Oizumi, Kozo Ohkusu-Tsukada and Kimimasa Takahashi (2010): Primary neuroblastoma in the skin of an adult Shih Tzu dog´. In: Veterinary Dermatology, Early View (Articles online in advance of print)
Published Online: 11 Mar 2010
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