Standard treatment included fluid resuscitation, antimicrobial therapy, supportive care, and surgery provided at the discretion of the primary clinician.
Blood was collected preoperatively and on days 1 and 3 postoperatively for platelet count, prothrombin time, activated partial thromboplastin time, D-dimer and fibrinogen concentrations, total protein C (PC) and antithrombin (AT) activities, and thromboelastography.
Measurements and Main Results: Sixteen of 27 (59%) dogs survived. Preoperative PC deficiency was identified in 10 of 11 (91%) nonsurvivors and 2 of 15 (13%) survivors.
Preoperative AT deficiency was identified in 10 of 11 (91%) nonsurvivors and 14 of 15 (93%) survivors.
Compared to survivors, nonsurvivors had lower mean preoperative PC (98 ± 24% versus 49 ± 26%; P < 0.001) and AT (53 ± 9% versus 32 ± 16%; P < 0.001) activities.
Anticoagulant activities decreased on day 1 postoperatively.
As a predictor of survival, preoperative PC activity of more than 60% achieved a sensitivity of 93% and specificity of 82%.
Preoperative AT activity of more than 41.5% achieved a sensitivity of 100% and specificity of 82%.
The maximum amplitude, α angle, and coagulation index from preoperative thromboelastograms of survivors were significantly greater (more hypercoagulable) than nonsurvivors (P < 0.01), with the maximum amplitude being the most specific predictor of survival (100%).
Conclusions: Deficiencies of PC and AT and hypercoagulability appear to be consistent features of naturally occurring canine sepsis and may be useful prognostic indicators in canine septic peritonitis.
Source: Bentley, A. M., Mayhew, P. D., Culp, W. T. N. and Otto, C. M. (2013), Alterations in the hemostatic profiles of dogs with naturally occurring septic peritonitis. Journal of Veterinary Emergency and Critical Care, 23: 14–22. doi: 10.1111/vec.12013
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