Six dogs with massive hepatocellular carcinoma that were ineligible for surgical resection or with owners who declined surgical resection, and underwent 3D-CRT were retrospectively reviewed.
6 to 10 Gy per fraction was prescribed at isocentre of planning target volume to a total dose of 18 to 42 Gy with 1 to 2 fractions per week for a total of 3 to 7 fractions.
Follow-up examinations included physical examination, contrast-enhanced CT scan and blood analysis (complete blood count, electrolytes and serum biochemical panel).
The median follow-up time after 3D-CRT was 534 (range, 281 to 1057) days.
An objective response was observed in five of six cases.
Radiation-induced liver disease developed in one dog but was asymptomatic and reversible.
Toxicity was not noted in any other dog.
3D-CRT appears to be a viable treatment option for dogs with inoperable massive hepatocellular carcinoma.
Source: Mori, T., Ito, Y., Kawabe, M., Iwasaki, R., Sakai, H., Murakami, M. and Maruo, K. (2015), Three-dimensional conformal radiation therapy for inoperable massive hepatocellular carcinoma in six dogs. Journal of Small Animal Practice, 56: 441–445. doi: 10.1111/jsap.12352
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