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3D-CRT in dogs with massive hepatocellular carcinoma
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Hepatic tumors often are either too big for surgical resection or the owner decline this operation. This recently online published study evaluates the activity and tolerability of three-dimensional conformal radiation therapy (3D-CRT) in six dogs with massive hepatocellular carcinoma.
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Six dogs with massive hepatocellular carcinoma that were ineligible for surgical resection or with owners who declined surgical resection, and underwent 3D-CRT were retrospectively reviewed.
6 to 10 Gy per fraction was prescribed at isocentre of planning target volume to a total dose of 18 to 42 Gy with 1 to 2 fractions per week for a total of 3 to 7 fractions.
Follow-up examinations included physical examination, contrast-enhanced CT scan and blood analysis (complete blood count, electrolytes and serum biochemical panel).
The median follow-up time after 3D-CRT was 534 (range, 281 to 1057) days.
An objective response was observed in five of six cases.
Radiation-induced liver disease developed in one dog but was asymptomatic and reversible.
Toxicity was not noted in any other dog.
3D-CRT appears to be a viable treatment option for dogs with inoperable massive hepatocellular carcinoma.
Source: Mori, T., Ito, Y., Kawabe, M., Iwasaki, R., Sakai, H., Murakami, M. and Maruo, K. (2015), Three-dimensional conformal radiation therapy for inoperable massive hepatocellular carcinoma in six dogs. Journal of Small Animal Practice, 56: 441–445. doi: 10.1111/jsap.12352
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Reference intervals for blood parameters in Shetland Sheepdogs
Several breeds have physiological peculiarities that induce variations in reference intervals (RIs) compared with the general canine population. Shetland sheepdogs (SSs) are reported to be more predisposed to different diseases (eg, hyperlipidemia, gallbladder mucocele, and hypothyroidism). Consequently, a breed‐specific approach is more often required. Thus, the aim of this study was to determine whether the RIs of the general canine population could be applied to that of SSs, and to generate breed‐specific RIs, where appropriate.
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