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Zonisamide in refractory canine epilepsy
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Epilepsy in dogs and men can be very frustrating to control. Which choices are the best if the `normal` drugs like phenobarbital are not effective? Zonisamide, a sulfonamide-derivate, is an antiepileptic for focal and generalized epilepsy in men. It has also some positive effects in dogs.
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12 dogs with poorly controlled primary epilepsy were included in this prospective non-comparative study. Oral zonisamide dose was adapted to the desired effective blood levels (10 to 40 ug/dl). The mean dose required was 8,9 mg/kg every 12 hours.
Seven dogs showed a favourable response with a mean reduction of the seizures of 81,3%. Five dogs unfortunately even showed an increased seizure frequency.
Mild side effects like transient sedation, vomiting and diarrhea were seen in 6 (50%) of the treated animals.
Source: Dewey CW, et al (2004): Zonisamide Therapy for Refractory Idiopathic Eiplepsy in Dogs. In: JAAHA 40:§, pp 270-284
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