Hematological parameters, plasma C-reactive protein (CRP), and tumor necrosis factor were analyzed in 64 dogs with a presumptive diagnosis of pyometra.
Final diagnosis (i.e., pyometra or cystic endometrial hyperplasia [CEH]) was determined by histopathology.
As a single test, the percentage of band neutrophils had the highest sensitivity in the prediction of pyometra (sensitivity, 94%). The combination of percentage of bands and CRP had the highest sensitivity (97.7%; specificity, 75%) in predicting the presence of pyometra. The most common clinical signs noted in the study were vaginal discharge, polyuria, polydipsia, lethargy, and gastrointestinal signs.
A combination of three or more of these clinical signs was significantly associated with pyometra.
Source: Boel A. Fransson, Erika Karlstam, Annika Bergstrom, Anne-Sofie Lagerstedt, Jean S. Park, Marc A. Evans and Claude A. Ragle (2004): C-reactive Protein in the Differentiation of Pyometra From Cystic Endometrial Hyperplasia/Mucometra in Dogs. In: Journal of the American Animal Hospital Association 40:391-399 (2004)
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