Chlorambucil is an alkylating agent. Neurotoxicity has been well recognized in human patients. Onsets of central nervous system signs, such as myoclonus, tremors, muscular twitching, agitation, and tonic-clonic seizures, have been reported in humans and laboratory animals treated with chlorambucil.
This case of a cat with intestinal lymphoma represents the first veterinary patient reported to have chlorambucil-induced neurotoxicity.
Therefore, neurotoxicity should be considered a potential side effect of chlorambucil therapy also in veterinary patients.
Source: Noémi Benitah, Louis-Philippe de Lorimier, Michele Gaspar, Barbara E. Kitchell (2003): Chlorambucil-Induced Myoclonus in a Cat With Lymphoma. In: Journal of the American Animal Hospital Association 39:283-287 (2003)
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