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Potassium bromide and the thyroid function in dogs
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Potassium bromide is a classic and still widely used antiepileptic drug. Less is known if it also decreases the thyroid hormone levels as other antiepileptics, e.g. phenobarbital, do. This placebo-controlled study answers the question: Potassium bromide does not appear to have a significant effect on canine thyroid function or morphology.
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A placebo-controlled experiment was performed to evaluate the effect of potassium bromide on the canine thyroid gland.
Basal total thyroxine, free thyroxine, and basal thyrotropin serum concentrations were evaluated over a 6-month period in potassium bromide-treated and control dogs.
A thyrotropin-releasing hormone stimulation test was also performed in all dogs at the beginning and conclusion of the study.
Thyroid histopathology was compared between treated and control dogs at the end of the study. No difference was detected in any parameter between the two groups at the end of the study.
A decline in thyroid hormone concentrations over the course of the study did occur in both groups of dogs.
Source: Lisa C. Paull, J. Catharine R. Scott-Moncrieff, Dennis B. DeNicola, Nita Glickman, Kent R. Refsal,Larry T. Glickman (2003): Effect of Anticonvulsant Dosages of Potassium Bromide on Thyroid Function and Morphology in Dogs. In: Journal of the American Animal Hospital Association 39:193-202 (2003)
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