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Mixed pancreatic acinar-endocrine carcinoma in a dog (case report)
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Pancreatic carcinomas are commonly seen in small animal medicine. They tend to be highly malignant, most of them being adenocarcinomas. This brandnew case report describes the first known case of a mixed acinar-endocrine carcinoma of the pancreas in an older dog, presented with intermittent hypoglycemia as the first sign. Very exciting!
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A 10.5-year-old crossbreed dog was presented with a history of hypoglycaemic episodes and elevated serum insulin concentration.
A pancreatic mass was removed at surgery along with an enlarged draining lymph node. An unresectable hepatic nodule was also present.
Immunohistochemistry confirmed the pancreatic and lymph node masses as functional mixed acinar-endocrine carcinoma, previously unreported in domestic species.
Persistent hypoglycaemia and hyperinsulinaemia post-operatively was highly suggestive of the hepatic mass being a functional metastasis. T
he dog was managed on prednisolone and remained asymptomatic 9 months post-operatively.
This tumour type has only been rarely reported in human patients and may highlight the need for more rigorous immunohistochemical staining of pancreatic masses in veterinary species to identify the prevalence of this tumour type.
Source: Belshaw, Z., Bacon, N. J., Foale, R. D., Mannion, P. M. & Reuter, R. (2005): Pancreatic mixed acinar-endocrine carcinoma in a dog. In: Veterinary and Comparative Oncology 3 (3), 145-148.
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