20 dogs with a proven pruritic malassezia dermatitis were included in the study.
Group A was treated with ketoconazole 5-10 mg/kg daily, group B was treated with itraconazole 5 mg/kg 2 times a week.
After 3 weeks, no statistical differences between the two groups regarding pruritus, clinical signs (evaluated by CADESI score) and number of Malassezia yeasts on cytological preparations were found.
Thus, itraconazole pulse therapy was considered to be as effective as daily ketoconazole in the therapy of canine malassezia dermatitis.
Source: Bensignor, E. (2005): Efficacy of itraconazole as a pulse therapy in canine malassezia dermatitis. In: Proceedings of the 20th Annual Congress of the ESVD-ECVD Chalkidiki, Greece, 8-10 September, 200f, p. 192
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