| |
Prolonged remission time after pemphigus foliaceus therapy in dogs
 |
Pemphigus foliaceus is one of the most common autoimmune diseases in dogs. Limited information is available on the long-term outcome of treatment of this disease. If life-long immunosuppressive therapy always mandatory? Interesting answers come from this study. It reports that a prolonged remission can occur after discontinuation of immunosuppressive regimens in some animals with this disease.
|
|
|
| |
Six dogs were diagnosed with pemphigus foliaceus based on suggestive clinical signs and histopathology.
These patients were treated either with immunosuppressive doses of oral glucocorticoids or with a combination of oral glucocorticoids and azathioprine.
After clinical signs underwent complete remission, which occurred 1.5-5 months after immunosuppression was initiated, the drugs were tapered progressively and eventually withdrawn.
The total duration of immunosuppressive therapy varied between 3 and 22 months.
Skin lesions of pemphigus foliaceus did not recur for 1.5-6 years after treatment was stopped.
These observations suggest that, in some dogs with pemphigus foliaceus, immunosuppression can lead to long-term remission of skin lesions, and that discontinuation of treatment is not necessarily followed by a recurrence of clinical signs.
Source: Olivry T, Bergvall KE, Atlee BA. (2004): Prolonged remission after immunosuppressive therapy in six dogs with pemphigus foliaceus. In: Vet Dermatol. 2004 Aug;15(4):245-52.
Tell a friend
|
Print version
|
Send this article
|
| |
Metastasis of a well differentiated perianal gland tumorPunica granatum associated with hepatotoxicosis in cattle Toceranib phosphate (Palladia®) in canine gastrointestinal stromal tumorsRadioactive iodine uptake in hyperthyroid cats after rh-TSHHypoechoic tissue changes in dogs with malignant prostatic lymphomaEmphysematous gastritis in dogs and catsPrimary pulmonary histiocytic sarcoma in dogsDetermining prognosis in canine sepsis Correlation of plasma and tear glucose, creatinine and urea nitrogen in catsPerineal hernias in dogs - always a bilateral problem?Pharmacokinetic of gabapentin in catsFollicular development of canine ovaries stimulated by eCG plus hCG
|
