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Funisitis associated with leptospiral infection in a horse
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Funisitis, inflammation of the umbilical cord, is well recognized in human placentas and not very common in horses. And Leptospira infections in horses are well-known to be involved in chronic eye infections. A very informative case report of a funisitis associated with leptospiral infection in the placenta of a Thoroughbred foal born prematurely.
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The umbilical cord had diffuse superficial yellow discoloration along its entire length.
Microscopic evaluation showed an exudate of neutrophils admixed with fibrin on the surface. WarthinStarry staining showed spirochetes in the Wharton`s jelly of the umbilical cord.
A locally extensive, severe placentitis not involving the star and allantoic cystic hyperplasia were the other lesions observed in the allantochorion.
Leptospira funisitis is similar to the funisitis of congenital syphilis in humans, although there are some major microscopic differences.
In Leptospira funisitis, lesions were limited to the cord surface, whereas in lesions in human umbilical cords with Treponema pallidum infection, the changes are observed mostly around the vessels and in the Wharton`s jelly.
Source: M. Sebastian, R. Giles, J. Roberts, K. Poonacha, L. Harrison, J. Donahue and K. Benirschke (2005): Funisitis Associated with Leptospiral Abortion in an Equine Placenta. In: Vet Pathol 42:659-662 (2005)
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Theiler´s disease in a Trakehner caused by contaminated tetanus vaccine
An 11‐year‐old Trakehner gelding was presented for evaluation of lethargy, decreased appetite, mild icterus, and elevated hepatic enzyme activities. Physical examination, serum chemistry results, and liver biopsy histopathologic findings were supportive of Theiler`s disease. Polymerase chain reaction (PCR) testing results of serum and liver tissue were positive for nonprimate (equine) hepacivirus (NPHV) and a novel equine parvovirus‐hepatitis virus (EqPV‐H). A serious and finally fatal problem, caused by contaminated vaccine.
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