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Acromegaly in cats
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Acromegaly is a rare problem in cats. But when it occurs, it is often caused by a pituitary neoplasia and can be very difficult to diagnose. One interesting and reliable sign: insulin-resistant diabetes mellitus!
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Acromegaly is characterized by chronic excessive growth hormone (GH) secretion by the pituitary gland. Feline acromegaly is most commonly caused by a functional pituitary tumor.
Definitive diagnosis can be difficult because of the gradual disease onset, subtle clinical signs, unavailability of relevant laboratory tests, and client financial investment.
The most significant clinical finding of acromegaly is the presence of insulin-resistant diabetes mellitus.
Diagnosis is currently based upon brain imaging and measurement of serum GH and/or insulin-like growth factor-1 concentrations.
Definitive treatment in cats is not well described, but radiation therapy appears promising.
Source: Charles A. Hurty, Bente Flatland (2005): Feline Acromegaly: A Review of the Syndrome. In: Journal of the American Animal Hospital Association 41:292-297 (2005)
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